Experimental Lp(a)-lowering drug pelacarsen fails to reduce cardiovascular events in 8,350-patient trial
Researchers reported at the American Heart Association meeting in Chicago that pelacarsen, an experimental drug that lowers lipoprotein(a), did not reduce major adverse cardiovascular events despite cutting Lp(a) levels substantially. The trial randomized 8,350 patients with prior cardiovascular events and elevated Lp(a) to the drug or placebo and followed them for about five years. Novartis, which sponsored the study, is abandoning the drug.
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Divergence score
2 outlets covered it, splitting into 2 framing camps across 1 bias group.
2 camps
1 bias group
Market signalBETA
The spectrum · how 2 outlets placed this story
LeftCenterRight
CNN
NPR
Supportive of action
Neutral
Dismissive
Critical
Alarmist
International angle
Widest split · the two outlets furthest apart, and who published first
Furthest apart on this story
CNN
A promising drug for an inherited heart risk flops, stunning doctors
Dramatic narrative of a busted blockbuster · negative
NPR
A promising new medicine against heart disease fails unexpectedly
Explanatory science reporting on what went wrong · neutral
First to report
- CNNfirst
- NPR+8.0 h
By each outlet's earliest publish time in this story. Feeds that index slowly can appear later than they printed.
The split, in one line
Both outlets lead with the same shock: a drug expected to work failed. CNN dwells on the gasp in the audience and the biology rethink; NPR adds the 78% Lp(a) drop and Novartis's statement.
How each outlet covered it
Lightly covered so far
Too few outlets to map a left-right split. Here is each take as it stands.
Sparse coverage · 2 outlets
“A promising drug for an inherited heart risk flops, stunning doctors”
“A promising new medicine against heart disease fails unexpectedly”
6 tracked claims across 2 outlets
Fact ledger
All6Claimed2Corroborated4
1/2
Claimed
Pelacarsen suppressed Lp(a) levels by about 78%
Corroborated
Disputed
5 more tracked claimsSign up free to see the full ledger